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Raymond N. DuBois, Jr., MD, PhD

Raymond N. DuBois, Jr., MD, PhD

Medical University of South Carolina, Charleston
Hollings Cancer Center

86 Jonathan Lucas Street, MSC 955
Charleston, SC 29425-2220

Phone: 843-792-9455

Assistant: Anita Harrell
Phone: (843) 792-2842

Member Since: 1994

Member Status: Fellow


Dean of Medicine



Clinical Interest(s)

Member of Executive Board of Directors for the MUSC practice plan

Research Interest(s)

  • Colorectal Cancer
  • Inflammation
  • Prostaglandins
  • Tumor microenvironment

Current / Former SSCI Roles

Past president of SSCI

About Raymond N. DuBois, Jr., MD, PhD

Raymond DuBois, MD, PhD, is an internationally renowned expert for his studies on the molecular and genetic basis for colorectal cancer. His laboratory examines the molecular mechanisms by which inflammatory mediators affect epithelial biology, the tumor microenvironment, carcinogenesis and development. Dr. DuBois was named Dean of the College of Medicine at the Medical University of South Carolina in March 2016. For four years prior to coming to MUSC, Dr. DuBois served as Executive Director of the Biodesign Institute at Arizona State University with a joint appointment as Professor of Medicine in the Mayo College of Medicine. He served as Provost and Executive Vice President and Professor of Cancer Medicine and Cancer Biology at The University of Texas MD Anderson Cancer Center in Houston from 2007-2012. From 1998 to 2004 he directed Vanderbilt’s Division of Gastroenterology, Hepatology and Nutrition, and served as Director of the Vanderbilt-Ingram Cancer Center from 2005-2007. DuBois discovered the critical and mechanistic role of prostaglandins (PGs)/cyclooxygenase in colon cancer, and its malignant progression. He also elucidated the role of PGs in the tumor microenvironment and spearheaded the now common use of drugs for human cancer prevention that target the PG pathway, like aspirin & other NSAIDs. This work led to a better understanding of the role of anti-inflammatory agents like aspirin and other NSAIDs in the tumor microenvironment . More recent studies have revealed that PGE2 regulates the immune status of the tumor microenvironment and inhibitors of PGE2 signaling block tumor metastasis. Dr. DuBois a Fellow of the American Association for the Advancement of Science and AACR, Past President of the American Association for Cancer Research, the Southern Society for Clinical Investigation, and the International Society for Gastrointestinal Cancer. He is also a member of the American Clinical and Climatological Association, the Royal College of Physicians, the Association of American Physicians and the American Society for Clinical Investigation. During his career as a physician-scientist, DuBois has published over 150 peer reviewed research articles, more than 60 article reviews, 25 book chapters, and three books. His work has been cited over 49,000 times according to Google Scholar. He is a co-inventor of a method to identify and prevent cellular genes needed for viral growth and cellular genes that function as tumor suppressors in mammals. DuBois earned a bachelor’s degree from Texas A&M University and a doctoral degree from The University of Texas Southwestern Medical Center in Dallas. He obtained a medical degree from The University of Texas Health Science Center in San Antonio, followed by an Osler Medicine internship and residency, and a gastroenterology fellowship at the Johns Hopkins Hospital in Baltimore.


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