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Highlights from the SSCI Nephrology Young Investigators' Forum

The 18th Annual Southeastern Regional Nephrology Young Investigators' Forum (NYIF), sponsored by the Southern Society for Clinical Investigation (SSCI) with generous support from an educational grant from AstraZeneca Pharmaceuticals, was held February 20, 2018, in New Orleans, LA. The NYIF served as a pre-course to the Annual Southern Regional/Southern Society for Clinical Investigation Meetings, which occurred February 21-23, 2019.

Postdoctoral fellow trainees in nephrology programs throughout the Southeast were invited to present their research at the NYIF, which continued in the pattern of previous meetings with all of the presentations representing superior quality research. This year, nineteen fellows representing twelve academic medical centers in eight states (Alabama, Tennessee, Georgia, Florida, Texas, North Carolina, Louisiana, and Virginia) were selected to participate. In addition to the nephrology fellow presenters and the panel of five judges, there were a number of mentors present for the meeting. The research presentations were divided into basic and clinical research categories with the morning devoted to clinical research presentations and the afternoon program dedicated to basic science talks. This year was a little different than prior years, as we had more preclinical abstracts (14) than clinical/translational abstracts (5). All those present contributed to a lively and constructive question-and-answer session following each of the presentations.

The event was initiated with a particularly excellent and relevant lecture entitled "My Life in Science: Lessons Learned from the Road Less Traveled" by Leslie Gewin, M.D., who is presently an Assistant Professor of Medicine in the Renal Division at Vanderbilt University. Dr. Gewin's research is funded by the National Institutes of Health and the Department of Veterans Affairs. Dr. Gewin described how she became a prominent researcher and reassured the young audience that motivation may be much more important than the focus of an undergraduate degree that may have not relevance to the work life you are pursuing. Her presentation was very well received by attendees.

Subsequent presenters all performed at a very high level, and their knowledge of their area of research and the background literature was impressive. Similarly, their ability to address wide-ranging and probing questions from the audience was equally impressive. This year's program, as with past programs, continued to reflect the superior investigative talent in nephrology training programs in the Southeast.

This year, awards were presented to the four top-rated presentations in each of the Clinical Science and Basic Science categories. An alternate was also selected in each category. The winners advanced to the National Nephrology Young Investigators Forum that will be held in conjunction with the 2018 Spring National Kidney Foundation Clinical Meeting. This year's award winners are:

Awards

Clinical Science Research Awards

  • 1st - Michael W. Holliday, Jr., MD, PhD, Baylor College of Medicine - Survey of Migrant Dialysis Patients Disclosures a Majority with Paraquat or Other Agrochemical Exposure: A Potential Etiology for Mesoamerican Nephropathy
  • 2nd - Daniel Edmonston, MD, Duke University - Impact of Pulmonary Hypertension Subtype on Mortality in Chronic Kidney Disease
  • 3rd - Crystal Farrington, DO, University of Alabama at Birmingham - The Microbiology, Clinical Presentation, and Complications of the Dialysis Catheter-Related Bloodstream Infections
  • 4th - Manuel E. Gonzalez, MD, Ochsner Clinic Foundation - Diagnostic Utility of Serial Microscopic Examination of the Urinary Sediment in Acute Kidney Injury
  • Alt. - none

Basic Science Research Awards

  • 1st - Anju Sreelatha, PhD, University of Texas Southwestern Medical Center - Protein AMPylation by an Evolutionarily Conserved Pseudokinase
  • 2nd - Shinji Tanaka, MD, PhD, University of Virginia - Both Efferent and Afferent Vagus Neurons Contribute to the Protective Effect of Vagus Nerve Stimulation in Acute Kidney Injury
  • 3rd - Sunil Rangarajan, MBBS, University of Alabama at Birmingham - Immunoglobulin Free Light Chains Cause Progressive Kidney Disease and Fibrosis via STAT1-Dependent Mechanisms
  • 4th - Selene Colon, PhD, Vanderbilt University Medical Center - Divergent Compartment Specific Roles for Peroxidasin After Kidney Injury
  • Alt. - Shirin Pourafshar, PhD, University of Virginia - Effect of Parenchymal versus Hematopoietic GSTM1 Deficiency on Renal Inflammation and Injury in Ang II-HTN

The value of this NYIF for the trainee participants is extraordinary. This unique setting provides a forum where fellows can present original research orally to a small group of peers. Often this is the first extramural opportunity for the trainee to present his/her work at a formal meeting. This setting provides a novel, non-threatening environment for presentation and discussion for fellows and among fellows from different training programs in the region. There are no other meeting venues or environments that allow this high level of oral presentation and personal interaction for this level of training. Between and after sessions, trainees are afforded the extraordinary opportunity to interact personally with their peer group of researcher-trainees from the region and nationally if selected to advance to the national meeting. They also interact with a panel of judges who comprise a group of senior nephrologists and program leaders in the Southeast. They have the opportunity to network with other trainees in the region and nationally. It should also be noted that a number of trainee presenters at earlier NYIF programs have graduated to become our new young academic faculty for a number of nephrology programs in the Southeast and elsewhere.

Participants uniformly commented that this type of forum is strongly needed by the community and offered a great opportunity for networking. Many of the trainees spontaneously remarked that the meeting was a resounding success and an outstanding event for fellow participation. All recommended participation in this forum for future nephrology fellows.

The presenters and title of their presentations follows:

Presentations

Welcome & Opening Remarks - Paul W. Sanders, MD
Thomas E. Andreoli Endowed Chair in Nephrology
Director, Nephrology Research & Training Center
University of Alabama at Birmingham

Keynote Address
My Life in Science: Lessons Learned from the Road Less Traveled
Leslie Gewin, MD
Assistant Professor of Medicine, Division of Nephrology
Vanderbilt University Medical Center

Clinical Science Presentations

CR-01 - Daniel Edmonston, MD, Duke University
Fibroblast Growth Factor 23 and Clinical Risk Prediction in Chronic Kidney Disease

CR-02 - Crystal Farrington, DO, University of Alabama at Birmingham
The Microbiology, Clinical Presentation, and Complications of the Dialysis Catheter-Related Bloodstream Infections

CR-03 - Manuel E. Gonzalez, MD, Ochsner Clinic Foundation
Diagnostic Utility of Serial Microscopic Examination of the Urinary Sediment in Acute Kidney Injury

CR-04 - Michael W. Holliday, Jr., MD, PhD, Baylor College of Medicine
Survey of Migrant Dialysis Patients Disclosures a Majority with Paraquat or Other Agrochemical Exposure: A Potential Etiology for Mesoamerican Nephropathy

CR-05 - Akihiro Kuma, MD, PhD, Emory University
Upregulation of a Urea Transporter in Uremic Heart is Linked to Cardiac Fibrosis

CR-06 - Devika Nair, MD, Vanderbilt University
Coping and Self-Management Behaviors in End-Stage Renal Disease

Basic Science Presentations

BS-01 - Mark G. Athanason, PhD, Vanderbilt University Medical Center
7S dodecamer of Collagen IV as Substrate of Lysyl Oxidase like-2 for the Screening of Inhibitory Compounds

BS-02 - Trayambak Basak, PhD, Vanderbilt University Medical Center
Pharmacological Inhibition of Lysyl Oxidase-like 2 Ameliorates Glomerulosclerosis in Diabetic Nephropathy

BS-03 - Selene Colon, PhD, Vanderbilt University Medical Center
Divergent Compartment Specific Roles for Peroxidasin After Kidney Injury

BS-04 - G. Ryan Crislip, PhD, University of Florida
Kidney-Specific Role of the Circadian Clock Protein BMAL1 in Blood Pressure Control in Male and Female Mice

BS-05 - Supapron Kulthinee, PhD, Tulane University Health Sciences Ctr
Interactions Between Purinergic P2X Receptors and Angiotensin AT1 Receptor In Regulating Renal Afferent Arteriolar Resistance in Angiotensin II Dependent Hypertension

BS-06 - Hao Liu, MD, University of Texas Southwestern Medical Center
Location and Role of Ctnnd1 in Glomerular Development

BS-07 - Riyaz Mohamed, PhD, Augusta University
Prevention of Vascular Congestion Improves Renal Recovery and Function Post Renal Ischemia Reperfusion in Male Spontaneous Hypertensive Rats (SHR)

BS-08 - Shirin Pourafshar, PhD, University of Virginia
Effect of Parenchymal versus Hematopoietic GSTM1 Deficiency on Renal Inflammation and Injury in Ang II-HTN

BS-09 - Sunil Rangarajan, MBBS, University of Alabama at Birmingham
Immunoglobulin Free Light Chains Cause Progressive Kidney Disease and Fibrosis via STAT1-Dependent Mechanisms

BS-10 - Fitra Rianto, MD, Emory University
Mice Lacking Inner Medullary Urea Transporters have Reduced Renal Fibrosis Following Unilateral Ureteral Obstruction

BS-11 - Ashish Solanki, MSc, PhD, Medical University of South Carolina
Recessive Mutations in the Kirrel Gene in Human Nephrotic Syndrome

BS-12 - Sreelatha, PhD, University of Texas Southwestern Medical Center
Protein AMPylation by an Evolutionarily Conserved Pseudokinase

BS-13 - Shinji Tanaka, MD, PhD, University of Virginia
Both Efferent and Afferent Vagus Neurons Contribute to the Protective Effect of Vagus Nerve Stimulation in Acute Kidney Injury

BS-14 - Bruna Visniauskas, PhD, Tulane University Health Sciences Center
Activation of Prorenin Receptor (PRR) Stimulates Production of TNF? and IL-6 in Murine Macrophages

Highlights from Current & Previous Years

Related Information

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